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OPRI has been leading the paradigm shift in real world evidence for the past 12 years, by delivering pragmatic clinical trials, disease registries and database research.
OPRI’s founder, Professor David Price, has been a pioneer in setting new quality standards for database research which are fully adhered to by the research institute.

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2020 Publications COPD

A comparison of the real-life clinical effectiveness of the leading licensed ICS/LABA combination inhalers in the treatment for COPD - Accepted in International Journal of Chronic Obstructive Pulmonary Disease

Extra-fine beclometasone dipropionate/formoterol fumarate vs double bronchodilation therapy in patients with COPD: a historical real-world non-inferiority study - Accepted in International Journal of Chronic Obstructive Pulmonary Disease

Advancing the Patient Experience (APEX) in COPD registry: Study design and strengths - Accpeted in Journal of the American Board of Family Medicine

Blood Eosinophil Count Predicts Treatment Failure and Hospital Readmission for COPD - Accepted in ERJ Open Research

The Long-Term Burden of COPD Exacerbations during Maintenance Therapy and Lung Function Decline - Accepted in International Journal of Chronic Obstructive Pulmonary Disease

Development of the Advancing the Patient EXperience (APEX) in COPD registry: a modified Delphi Study - Accepted in Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation

Association between COPD exacerbations and lung function decline during maintenance therapy - Accepted in Thorax

Adequacy of therapy for people with both COPD and heart failure in the UK: historical cohort study - Accepted in Pragmatic and Observational Research

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2020 Publications | Severe Asthma

International severe asthma registry (ISAR): protocol for a global registry - Accepted in BMC Medical Research Methodology

Potential severe asthma hidden in UK primary care - JACI In Pract (Severe Asthma)

Biomarkers

Blood Eosinophil Count Predicts Treatment Failure and Hospital Readmission for COPD - ERJ Open Research

Other Studies

Historical database cohort study addressing the clinical patterns prior to idiopathic pulmonary fibrosis (IPF) diagnosis in UK primary care - Accepted in BMJ Open

Comparative safety profile of the fixed-dose combination corticosteroid and long-acting β2-agonist fluticasone propionate/formoterol fumarate: a 36-month longitudinal cohort study in UK primary care - Drugs

Opportunities to diagnose fibrotic lung diseases in routine care: a primary care cohort study - Respirology

Strategies that promote sustainability in quality improvement activities for chronic disease management in healthcare settings: A Practical Perspective

Evaluating the Real-life Effect of MP-AzeFlu On Asthma Outcomes In Patients With Allergic Rhinitis and Asthma In UK Primary Care - WAO J

A multinational observational study exposing the burden and impact of self-reported concomitant rhinitis and identifying primary care patients at risk of asthma exacerbations - Accepted in Journal of Asthma and Allergy

Publications
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2020 PUBLICATIONS
2019 PUBLICATIONS
2020 ACCEPTED ABSTRACTS

2019 Publications

Severe Asthma

Characterization of Severe Asthma Worldwide: Data From the International Severe Asthma Registry - Accepted in CHEST

International Severe Asthma Registry: Mission Statement - Accepted in CHEST

COPD

Inhaled corticosteroids in COPD and onset of type 2 diabetes and osteoporosis: matched cohort study - NPJ Primary Care Respiratory Medicine

Comparative effectiveness of triple therapy versus dual bronchodilation in COPD - Accepted in ERJ Open Research

Other Studies

A multinational observational study identifying primary care patients at risk of overestimation of asthma control - Accepted in NPJ Primary Care Respiratory Medicine

Management of community-acquired pneumonia: an observational study in UK primary care - Accepted in Pragmatic and Observational Research

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2020 PUBLICATIONS
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AAAAI 2020 Annual Meeting

Asthma-Related Outcomes in A Real-World Study of MP-AzeFlu to Treat Allergic Rhinitis
Evaluating the Real-life Effect of MP-AzeFlu On Asthma Control In Patients With Allergic Rhinitis and Asthma In UK Primary Care

REG 2020

Cluster analysis according to biomarker profile differentiates clinical subgroups in the International Severe Asthma Registry (ISAR)

The Demographic and Clinical Characteristics of Eosinophilic and non-Eosinophilic Phenotypes of Severe Asthma in International Severe Asthma Registry (ISAR)
Demographic and Clinical Characteristics of Patients with Severe Asthma who Continued, Stopped or Switched Biologic Therapy

COPD Primary Care: Providing a Clinically Relevant Picture for Clinicians

Publications
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2020 PUBLICATIONS
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ATS 2020

The Impact of Exacerbation Burden on Lung Function Trajectory in a Broad UK Asthma Population: A Large Longitudinal Cohort Study

Global Access for Biologics in the Treatment of Severe Asthma: A Challenge to Personalized Medicine

Biologic Utilization Patterns: Data from the International Severe Asthma Registry (ISAR)

A Global Survey of Blood Eosinophil Distribution in Severe Asthma Patients: Data from the International Severe Asthma Registry (ISAR)

Characterization of Eosinophilic and Non-Eosinophilic Severe Asthma Phenotypes and Proportion of Patients with These Phenotypes in the International Severe Asthma Registry (ISAR)

Biomarker Relatability in the International Severe Asthma Registry

Disease Burden for Patients with Chronic Obstructive Pulmonary Disease Receiving Maintenance Therapy

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