Uncontrolled and Severe Asthma

OPRI’s inaugural R&D program within Singapore focuses on ‘’Uncontrolled & Severe Asthma: Novel Risk & Therapeutic Response PredictionMaximising the Value of Future Interventions’’ commenced in 2015, in consultation with its affiliate research unit in the UK. The objectives of the program are defined as follows:

  • acquiring new knowledge within the field of uncontrolled and severe asthma through conducting novel systematic, investigative and experimental (SIE) studies
  • enabling the creation of new therapeutic strategies and novel risk prediction processes which address the current burden of uncontrolled and severe asthma in Singapore and globally and to maximize the value of future interventions
  • informing the improvement of existing therapeutic strategies or processes to address the current burden of uncontrolled and severe asthma in Singapore and globally and to maximize the value of future interventions

In order to meet the program objectives, leading professionals within the field have prioritised three key research themes/projects which were based on the scientific challenges that need to be overcome in order to acquire new knowledge that informs the creation of new products or processes; or improves existing products or processes. These are summarised below:

 

Research & Development Program

Uncontrolled & Severe Asthma: Novel Risk & Therapeutic Response Prediction

R&D Themes SIE Acitivites Duration R&D Country
Inhaler Devices CRITical Inhaler mistaKes and Asthma control (CRITIKAL) 2014-2017 SG
Health Care Professional Easy Low Instruction Over Time (HCP ELIOT) 2014-2018 SG
 Device Adherence Study Group (DASG) 2015-2019 SG
Biomarkers Non-Specific Respiratory Symptoms (NSRS) 2013-2017 SG
To be assigned (TBA)
Severe Asthma Impact of exacerbation burden on lung function trajectory 2017-2023 SG
Assess the overlap of collected biomarkers in severe asthma 2017-2023 SG